General topics like queue handling, queues and similar are covered in the gaussian wiki entry.
Basic syntax of crest submission script is following:
cnorris@lilo7:~$ Crest structure.xyz
where structure.xyz is the structure which you want to submit.
More advanced syntax looks like this:
cnorris@lilo7:~$ Crest structure.xyz -chrg 1 -uhf 0 -quick
Here I've added quick keyword which makes the screening less in-depth but it goes much quicker. I also added chrg keyword to define charge and uhf keyword to define spin state. For more detailed description and full list of keywords, please refer to crest command line arguments documentation.
Once calculation is finished, conformers list and best structure from crest structure pool is received. There is also a folder where rotamers file and other files are stored.
As Crest uses very cheap calculations, the energies are not fully reliable. After running crest you should go through the conformers list, pick the conformations which differ substantially (preferably ~10 structures) and run them with a more precise calculation (for example #B97/SDD opt in Gaussian). Based on the outcome of this second calculation batch you should decide which structures you want to submit for expensive calculations, frequencies jobs and similar.
Crest is a metadynamics tool which is very useful for generating low-energy structure candidates. The crest-best does not have to be the best structure, but the set of structures (crest-conformers) usually has the best available conformers within. Crest is a powerful and very useful tool, but it should not be used uncritically. Keep attention to the correct definition of charge and spin. If you think there is a way to improve this guide, please contact me (Jan).
Happy computing! ;)